ARCHIVED NEWS

NCI Community Oncology Research Program Expands to More States

August 19, 2019

NCI Community Oncology Research Program Expands to More States
Alliance Boasts 27 NCORP Community Sites | 12 Minority/Underserved Community Sites | 1 Research Base
 
The National Cancer Institute (NCI) has awarded 53 grants to researchers in the  NCI Community Oncology Research Program (NCORP) to conduct multi-site cancer clinical trials and cancer care delivery studies in their communities.


New Trial: Alliance A071701 Genetic Testing/Brain Metastases

August 15, 2019

Alliance A071701: Genomically-guided treatment trial in brain metastases

Overview:
Alliance investigator Priscilla Brastianos, MD, of Massachusetts General Hospital, leads this phase II trial that looks at how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several genes have been found to be altered or mutated in brain metastases such as NTRK


New Trial: Alliance A051701 High Grade B-Cell Lymphomas

August 6, 2019

Alliance A051701: Randomized phase II/III study of venetoclax (ABT199) plus dose-adjusted EPOCH-R for MYC/BCL2 double-hit and double protein expressing lymphomas

Overview: Alliance investigator Jeremy Abramson, MD, of Massachusetts General Hospital Cancer Center, leads this phase II/III trial that looks at whether it is possible to decrease the chance of high-grade B-cell lymphomas returning or getting worse b


Call for Nominations + Applications: Alliance Awards + Opportunities

July 9, 2019

Alliance Nursing Liaisons. The Alliance Oncology Nursing Committee (A-ONC) invites applications for two nursing liaison positions (one each) for the Alliance Lymphoma Committee and Alliance Respiratory Committee (click each link for specific details). The deadline for applications is July 22, 2019

Alliance Scholar Awards. These are two-year, non-renewable cancer research grants of $40,000 dire


Funding Support: Call for Applications & Nominations

June 25, 2019

The Alliance for Clinical Trials in Oncology makes available a variety of funding opportunities for Alliance members and investigators. Take a look at the opportunities below and feel free to nominate or apply for any that align with individual goals or seem ideal for a colleague. 

Jimmie Holland Lecturer. This lecturer is an investigator whose research has resulted in a major impact in the field of psycho


Call for Nominations: 2019 Jimmie C. Holland Lecturer

June 7, 2019

Jimmie C. Holland, MD, founded the field of psycho-oncology, a discipline devoted to studying psychological, social, and behavioral factors that may affect outcomes in patients with cancer. Dr. Holland was a leader in the CALGB/Alliance and has trained many Alliance cancer clinicians and researchers in this field. Dr. Holland's groundbreaking research has vastly improved overall treatment outcomes by increasing our


New Trial: Alliance A221702 Axillary Reverse Mapping/Breast Cancer

May 31, 2019

Alliance A221702: Axillary Reverse Mapping: A prospective trial to study rates of lymphedema and regional recurrence after sentinel lymph node biopsy and sentinel lymph node biopsy followed by axillary lymph node dissection with and without axillary reverse mapping (ARM)

Overview: Alliance investigator V. Suzanne Kimberg, MD, PhD, of the University of Texas Medical Branch at Galverston, leads this pha


Alliance Holiday Closures - Memorial Day

May 21, 2019

The Alliance Office of the Group Chair, Alliance Chicago Office, and the Alliance Statistics and Data Center will be closed on Monday, May 27 in observance of Memorial Day. Alliance Biorepositories and McKesson's Clinical Research Services will also be closed on Monday, May 27. For specific details, review the McKesson memoBioMS holiday schedule or contact the Clinical Research Services team at 800-693-4903 or clinicalr


Alliance Appoints New Committee Chairs

May 20, 2019

Anthony Jaslowski, MD, will serve as new Chair of the Alliance Constitution and Bylaws Committee. He succeeds Bruce A. Peterson, MD, of the University of Minnesota/Masonic Cancer Center. Dr. Jaslowski is the Principal Investigator of the Wisconsin NCI Community Oncology Research Program and Medical Director of HSHS St. Vincent Cancer Research Institute. He is also Chair of the Department of Oncology and Cancer Committee at Green Bay


New Trial: Alliance A091802 Skin Cancer

May 17, 2019

Alliance A091802: Phase II randomized trial of avelumab plus cetuximab versus avelumab alone in advanced cutaneous squamous cell carcinoma of the skin (cSCC)

Overview: Alliance investigator Dan P. Zandberg, MD, of the University of Pittsburgh Medical Center Hillman Cancer Center, leads this phase II Alliance trial looks at how well avelumab with or without cetuximab work in treating patients with skin squamous cell cancer that h


Alliance NCTN/NCORP/AFT at 2019 ASCO

May 16, 2019

 



Alliance NCTN/AFT at 2019 ASCO

The 55th Annual Meeting of the American Society of Clinical Oncology (ASCO) will convene in Chicago May 31-June 4 with Alliance Group Chair Monica M. Bertagnolli, MD, completing her 2018-2019 term as ASCO President. The ASCO meeting brings together more than 32,000 oncology professionals from around the world. This year's meeting theme is "Caring for Every Patient, Learning f


New Trial: Alliance A031704 Renal Cell Cancer

May 9, 2019

Alliance A031704 - PD-inhibitor (nivolumab) and ipilimumab followed by nivolumab vs. VEGF TKI cabozantinib with nivolumab: A phase III trial in metastatic untreated renal cell cancer (PDIGREE)

Overview: Alliance investigator Tian Zhang, MD, of the Duke University Medical Center, leads this phase III Alliance trial looks at how well nivolumab and ipilimumab, followed by nivolumab versus cabozantinib and nivolumab, work in tr


New Trial: Alliance A031702 Rare GU Tumors

April 15, 2019

Alliance A031702 - Phase II study of cabozantinib in combination with nivolumab and ipilimumab in rare genitourinary tumors

Alliance investigator Andrea Apolo, MD, of the NCI Center for Cancer Research, leads this phase II trial to see how well cabozantinib s-malate, nivolumab, and ipilimumab work together in treating patients with genitourinary tumors that have spread to other places in the body. Cabozantinib s-malate may


Primary Study Results: CALGB/Alliance 50303 (Diffuse Large B-Cell Lymphoma Trial) Now Online

April 5, 2019

Primary study results for CALGB/Alliance 50303 (Phase III randomized study of R-CHOP vs. dose-adjusted EPOCH-R with molecular profiling in untreated de novo diffuse large B-cell lymphomas) are now available online in the Journal of Clinical Oncology. The trial compared the event-free survival of standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHO


New Trial: Alliance A231601CD Improving Surgical Care/Outcomes for Older Cancer Patients

April 5, 2019

 

Alliance A231601CD - Improving surgical care and outcomes in older cancer patients through implementation of an efficient pre-surgical toolkit (OPTI-Surg)

Alliance researcher George J. Chang, MD, MS, of the University of Texas MD Anderson Cancer Center, leads a trial to see how well the use of a pre-surgical toolkit (OPTI-Surg) works in improving surgical care and out


New Trial: Alliance A231602CD Financial Toxicity (Blood Cancers) Trial

March 15, 2019

Alliance A231701CD - Assessing financial difficulty in patients with blood cancers

Alliance researcher Rena Conti, PhD, of the Boston University Questrom School of Business, leads a trial that seeks to better understand the range of financial difficulties experienced by patients with multiple myeloma (MM) or chronic lymphocytic leukemia (CLL) who are currently undergoing or have foregone treatmen


New Trial: Alliance A231701CD Decision Making Intervention Trial

March 5, 2019

Alliance A231701CD - Increasing socioeconomically disadvantaged patients' engagement in breast cancer surgery decision making through a shared decision making intervention

Alliance researcher Heather B. Neuman, MD, of the University of Wisconsin School of Medicine and Public Health, leads a limited access trial on how well a breast cancer surgery decision aid works in increasing patient engagement i


New Trial: Alliance A221701 Oral Stomatitis

February 22, 2019

Alliance A221701 - Phase III placebo-controlled trial to evaluate dexamethasone use for everolimus-induced oral stomatitis: Prevention versus early treatment approaches

Alliance researcher Kathryn J. Ruddy, MD, of Mayo Clinic, leads a new phase III trial looks at how well dexamethasone works in reducing everolimus-induced oral stomatitis in patients with cancer. Dexamethasone may help to reduce the everolimus-induced or


New Trial: Alliance A041701 Acute Myeloid Leukemia

January 16, 2019

Alliance A041701 - A randomized phase II/III study of conventional chemotherapy +/- uproleselan (GMI-1271) in older adults with acute myeloid leukemia receiving intensive induction chemotherapy

Alliance researcher Geoffrey L. Uy, MD, of Washington University - Siteman Cancer Center, leads a new phase II/III trial that looks to study how well daunorubicin and cytarabine with or without uproleselan works in treating


New Trial: Alliance A041702 Chronic Lymphocytic Leukemia (CLL)

January 7, 2019

*** FIRST ACTIVATION OF 2019 ***

Alliance A041702 - A randomized phase III study of ibrutinib plus obinutuzumab versus ibrutinib plus venetoclax and obinutuzumab in untreated older patients (>70 years of age) with chronic lymphocytic leukemia (CLL)

Alliance researcher Jennifer Woyach, MD, of Ohio State University, leads a new trial that looks at how well ibrutinib and obinutuzumab with or wi


Alliance News Vol 8 No 6

December 20, 2018

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Alliance Research in Spotlight | 2018 SABCS Meeting

December 4, 2018

The Alliance for Clinical Trials in Oncology will present three abstracts at this year's 41st Annual San Antonio Breast Cancer Symposium December 4-8 in San Antonio, TX. The symposium is designed to provide state-of-the-art information on the experimental biology, etiology, prevention, diagnosis, and therapy of breast cancer and premalignant breast disease, to an international audience of academic and private phy


New Trial: Alliance A041703 Acute Lymphoblastic Leukemia

December 3, 2018

Alliance A041703 - A phase II study of inotuzumab ozogamicin followed by blinatumomab for Ph-negative CD22-positive B-lineage acute lymphoblastic leukemia in newly diagnosed older adults or adults with relapsed or refractory disease

Alliance researcher Matthew Wieduwilt, MD, PhD, of University of California San Diego, leads a new trial that looks to study how well inotuzumab ozogamicin and blinatumomab work


CLL Trial Results (Alliance A041202) Published in New England Journal of Medicine

December 3, 2018

Hats off to Jennifer Woyach, MD (of Ohio State University) and the Alliance A041202 Study Team! Results from this study have just been published in the New England Journal of Medicine. The results indicate that among older patients with untreated chronic lymphocytic leukemia (CLL), treatment with ibrutinib, either alone or in combination with rituximab, was superior to treatment with ben


Sad News | Arti Hurria, MD
Co-Chair, Alliance Cancer in the Older Adult Committee

November 13, 2018

Members and staff of the Alliance for Clinical Trials in Oncology are deeply saddened by the loss of our dear colleague Arti Hurria, MD, who died November 7 as a result of injuries sustained in an automobile accident.
 
A leader in the field of geriatric oncology, Dr. Hurria dedicated her career to making sure that older adults with cancer received care that served them best.


Monica Bertagnolli, MD Re-Elected Alliance Group Chair

November 4, 2018

Monica M. Bertagnolli, MD, has been re-elected to serve as the Group Chair of the Alliance for Clinical Trials in Oncology for another five-year term. The election was held November 2 at the 2018 Alliance Fall Group Meeting in Chicago, IL.
 
Dr. Bertagnolli is Chief of the Division of Surgical at Dana-Farber/Brigham and Women's Cancer Center, a Professor of Surgery at Harvard Medical School, and an As


Alliance News Vol 8 No 5

October 23, 2018

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Sad News | David J. Sugarbaker, MD
Founding Chair, CALGB Surgery Committee
Renowned Thoracic Surgeon

August 29, 2018

David J. Sugarbaker, MD, passed away suddenly on Wednesday, August 29. Dr. Sugarbaker served as the founding Chair of the Surgery Committee for CALGB, prior to the merger that created the Alliance. He was the Principal Investigator of a grant from the NCI that re-vitalized and dramatically expanded surgeon participation in cooperative group research, prior to the cr


Two New Trials - Alliance A031701 (Bladder Cancer) and A211601 (Breast Cancer)

August 14, 2018

Alliance researcher Gopakumar Iyer, MD, of Memorial Sloan Kettering Cancer Center, leads a new trial (A031701) that looks at how well drugs (gemcitabine hydrochloride and cisplatin) work in treating patients with invasive bladder urothelial cancer. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by


Call for Nominations: 2019 Charles G. Moertel Lecturer

July 20, 2018

The Moertel Lecture Endowment Fund was established at Mayo Clinic to honor the legacy of Charles Moertel as the founder of the North Central Cancer Treatment Group (NCCTG), one of the three legacy groups that formed the Alliance. Dr. Moertel was known for his dedication to high-quality clinical research that provided practice-changing evidence to benefit patient care in the community setting.

The Moertel Lecture


New Trial: Alliance A021602 Neuroendocrine Tumors

July 18, 2018

Alliance researcher Jennifer Chan, MD, MPH, of Dana-Farber Cancer Institute, leads a new trial (A021602) that looks at the drug cabozantinib S-malate to see how well it works compared with placebo in treating patients with neuroendocrine tumors previously treated with everolimus that have spread to nearby tissues or lymph nodes or to other places in the body, or cannot be removed by surgery.

Alliance A021602 - Randomi


In Memoriam: Robert Harrison, Alliance Patient Advocate

July 18, 2018

Robert Harrison, a research advocate and patient advocate, died July 17. He was 74. Mr. Harrison served as a Patient Advocate for the Alliance Genitourinary (GU) Committee since 2016.

Mr. Harrison hailed from Clayton, North Carolina. He was the founding President of the Patient and Family Advisory Board at North Carolina Cancer Hospital (NCCH) in Chapel Hill and a patient advocate for three university-based canc


In Memoriam: Hank Porterfield, Alliance Patient Advocate

July 12, 2018

Hank Porterfield, a research advocate and patient advocate, died July 4. He was 95. Mr. Porterfield served as a Patient Advocate for the Alliance/CALGB Genitourinary (GU) Committee and Alliance/CALGB Prevention Committee for more than 15 years. He retired in November 2017 from the Alliance.

Mr. Porterfield was also a founding member and Chair of Us TOO International, an advocacy group focusing on prostate cance


Call for Applications | 2019 Alliance Scholar Award

July 10, 2018

The Alliance for Clinical Trials in Oncology Foundation invites applications for the 2019 Alliance Scholar Awards! Applications must be submitted by midnight CST July 31, 2018.
 
Alliance Scholar Award applicants must be oncology junior faculty at Alliance institutions within five (5) years of training (rank below Associate Professor), who have completed training in an oncology clinical specialty (e.g., medical


Alliance News Vol 8 No 3

July 2, 2018

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Alliance Office Closures - Independence Day

June 27, 2018

The Alliance Office of the Group Chair, Alliance Chicago Office, and the Alliance Statistics and Data Center will be closed on Wednesday, July 4 in observance of Independence Day. Alliance Biorepositories and McKesson's Clinical Research Services will also be closed on Wednesday, July 4. For specific details, review the BioMS holiday schedule or contact the Clinical Research Services team at 800-693-4903 or clinicalresearc


Alliance Office Closures-Memorial Day

May 24, 2018

 

The Alliance Office of the Group Chair, Alliance Chicago Office, and the Alliance Statistics and Data Center will be closed on Monday, May 28 in observance of Memorial Day.
 
Alliance Biorepositories and McKesson's Clinical Research Services will also be closed on Monday, May 28. For specific details, review the BioMS holiday schedule or contact the Clinical Research Services team at 800-693-4903 or clinic


Alliance NCTN at 2018 ASCO

May 18, 2018

The 54th Annual Meeting of the American Society of Clinical Oncology (ASCO) will convene in Chicago June 1-5 with Alliance Group Chair Monica M. Bertagnolli, MD, at the helm as ASCO President for the 2018-19 term. The ASCO meeting brings together more than 30,000 oncology professionals from around the world. This year's meeting theme is "Delivering Discoveries: Expanding the Reach of Precision Medicine."  Studies spanning the


Alliance for Clinical Trials in Oncology Foundation Turns 25!

May 4, 2018

Since 1993, the Alliance for Clinical Trials in Oncology Foundation has raised funds to help the Alliance for Clinical Trials in Oncology answer important cancer research questions through large-scale clinical trials and laboratory research.

The Alliance for Clinical Trials in Oncology Foundation turns 25 this month!

Helping find new ways to prevent, treat and cure many types of cancer, including


Upcoming Group Meeting Highlights | Spring 2018

April 27, 2018

The Alliance for Clinical Trials in Oncology will convene its 2018 Spring Group Meeting in Chicago May 10-12. Scientists, clinical research professionals, patient advocates and others interested in the latest developments in cancer research are expected to attend the four-day meeting at the Loews Chicago O'Hare Hotel. Meeting attendees will select from nearly 100 disease, modality, administrative and special sessions t


Alliance Appoints Associate Group Chair for Strategic Initiatives and Innovation

April 18, 2018

Steven Piantadosi, MD, PhD, will join the Alliance Executive Committee as the Associate Group Chair for Strategic Initiatives and Innovation. Dr. Piantadosi will also join the Alliance Statistics and Data Management Program, under the direction of Sumithra Mandrekar, PhD, Alliance Group Statistician. He will be located in the Alliance Group Chair's Office in Boston, where he has recentl


Alliance News Vol 8 No 2

April 16, 2018

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In Memoriam: Karen Durham, Alliance Patient Advocate

March 30, 2018

 

Karen Durham, a research advocate and patient advocate, died March 26. She was 66. Mrs. Durham served as a Patient Advocate for the Alliance Health Outcomes Committee and Alliance Community Oncology Committee since 2016. A highly-respected advocate for breast cancer patients and research, Mrs. Durham was selected as a Susan G. Komen Scholar and Advocates in Science Steering Committee member and served local


Global Cancer Trial Sets New Standard for Post-Surgery Chemotherapy

March 29, 2018

Some stage III colon cancer patients can cut in half the number of chemotherapy treatments they receive after surgery, significantly reducing the costs, treatment time, and long-term toxic effects of chemotherapy, according to results of a unique global clinical trial collaboration published for the first time in the New England Journal of Medicine.

Results show that for some colon cancer pati


In Memoriam: James F. Holland, MD - Pioneer in the Field of Medical Oncology

March 23, 2018

In Memoriam: james F. holland, md
pioneer in the field of medical oncology

James F. Holland, MD, a pioneer in the field of medical oncology, died March 22. He was 92. Dr. Holland was one of the founding members of Cancer and Leukemia Group B (CALGB). He served as Group Chair of CALGB from 1963 to 1981. At the time of his death, he was the Distinguished Professor of Neoplastic Diseases at


Alliance News Vol 8 No 1

March 6, 2018

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Alliance Research in Spotlight: 2018 Genitourinary Cancers Symposium February 8-10

February 8, 2018

The Alliance for Clinical Trials in Oncology will present an abstract from its study portfolio during the 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care this week in San Francisco, CA. The annual symposium gives physicians and other members of the cancer care and research community who diagnose, treat, and study genitourinary malignancies the opport


Two New Alliance Trials Open for Patients with Lung Cancer, Rare Skin Cancer

February 2, 2018

The Alliance for Clinical Trials in Oncology this week opened two new trials for treating patients with Merkel cell cancer, a rare type of skin cancer, and for patients with breast cancer who have undergone mastectomy.

Alliance A091605: A randomized phase II study of anti-PD1 antibody [MK-3475 (pembrolizumab)] alone versus anti-PD1 antibody plus stereotactic body radiation therapy in adva


Alliance Research Spotlight: 2018 Gastrointestinal Cancers Symposium January 18-20

January 19, 2018

The Alliance for Clinical Trials in Oncology will present three abstracts from its study portfolio during the 2018 Gastrointestinal Cancers Symposium this week in San Francisco, CA. The annual symposium features multidisciplinary topics of international interest, including cancers of the esophagus and stomach, pancreas, small bowel and hepatobiliary tract, and the colon, rectum and anus


In Memoriam: Jimmie C. Holland, MD - Pioneer in the Field of Psycho-Oncology

December 27, 2017

Jimmie C. Holland, MD, a pioneer in the field of psycho-oncology, died December 25. She was healthy and active up to the day of her passing, at the age of 89. So few individuals can be credited with changing cancer care world wide, and Dr. Holland was one of them. Those of us in the Alliance are so very fortunate that she was among the founders of our group.

Dr. Holland established the


In Memoriam: Patrick Gavin, RPh, Co-Chair, Alliance Patient Advocate Committee

December 20, 2017

Patrick Gavin, RPh, a research advocate who brought the patient voice and perspective to the research table, died December 18. He was 68. Mr. Gavin served as Co-Chair of the Alliance Patient Committee and on the Board of Trustees of the Alliance for Clinical Trials in Oncology Foundation. He was also a patient advocate for neuro-oncology cancer research. His numerous contributions to the f


Alliance News Vol 7 No 5

December 19, 2017

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Alliance Research in Spotlight: 2017 SABCS Meeting December 5-9

December 12, 2017

ALLIANCE RESEARCH IN SPOTLIGHT  
2017 SABCS MEETING DECEMBER 5-9

The San Antonio Breast Cancer Symposium (SABCS) provides state-of-the-art information on breast cancer research. SABCS is a five-day program attended by a broad international audience of academic and private researchers and physicians from more than 90 countries. Its goal is to achieve a balance of clinical, translational, and ba


Alliance Research in Spotlight: 2017 ASH Meeting December 9-12

December 7, 2017

The American Society of Hematology (ASH) is the world's largest professional society serving both clinicians and scientists who are working to conquer blood diseases. ASH represents more than 17,000 members from nearly 100 countries. The Alliance for Clinical Trials in Oncology will present an array of novel data from many of its hematology studies during the 59th ASH Annual Meeting and Exposition Dece


Alliance Statistics and Data Center Announce Recipient of Inaugural Daniel J. Sargent, PhD, Memorial Fellowship in Innovative Clinical Trial Design and Methods

September 19, 2017

The Alliance Statistics and Data Center is pleased to announce Vivien (Jun) Yin, PhD, as the first recipient of the Daniel J. Sargent, PhD, Memorial Fellowship in Innovative Clinical Trial Design and Methods. Dr. Yin is an Assistant Professor of Biostatistics,an Associate Consultant at Mayo Clinic, and Facult


Ann L. Oberg, PhD, Appointed Associate Group Statistician

September 12, 2017

The Alliance for Clinical Trials in Oncology is pleased to announce the appointment of Ann L. Oberg, PhD, as the Associate Group Statistician of the Alliance Statistics and Data Center.

Dr. Oberg is a Professor of Biostatistics at Mayo Clinic and has extensive experience as a statistician, collaborating to obtain and carry out numerous funded grants. Her experience is primarily in cancer and vaccine resea


Alliance Cancer Control Program Presents Funding Awards to Six Investigators

September 11, 2017

Six Alliance investigators have been selected to receive funding awards through the Alliance NCORP Research Base. The Alliance NCORP Research Base, which is supported by the NCI Division of Cancer Prevention (DCP), supports Alliance researchers and junior investigators and their work through annual funding awards: Alliance Cancer Control Program Pilot (CCP) Project Award and Alliance CCP Ju


Registration Open | 2017 Alliance Fall Group Meeting

August 22, 2017

Registration for the 2017 Alliance Fall Group Meeting November 2-4 in Chicago, IL is now open. Visit the Alliance Meeting Webpage or Cvent to manage your registration.

Travelers who are funded directly by the Alliance should have received an invitation by e-mail to register for the meeting.

If you have questions, please contact Samantha Berg, Alliance Meetings and Operations Coordinator, by e-mail sber


AFT Launches PATINA Trial | HR+ HER2+ Metastatic Breast Cancer

August 22, 2017

The Alliance Foundation Trials, LLC (AFT), in conjunction with Pfizer and six international cancer research groups, today announced the launch of PATINA- a randomized, open-label, phase 3 clinical study of the cyclin-dependent kinase 4/6 (CDK 4/6) inhibitor palbociclib (also known as IBRANCE®). The PATINA trial will evaluate palbociclib in combination with anti-HER2 therapy and endocrine therapy versus


Alliance News Vol 7 No 3

August 1, 2017

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Alliance at ASCO 2017

May 18, 2017

 

 

 

 

 

 

 

 

The 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO) will convene in Chicago June 2-6, bringing together more than 30,000 oncology professionals from around the world. This year's meeting theme is "Making a Difference in Cancer Care with You." Studies spanning the spectrum of cancer prevention an d care, from immunotherap


CALGB (Alliance) 10603 RATIFY Study Results Lead to FDA Approval of New Combination Treatment for Acute Myeloid Leukemia

April 28, 2017

The U.S. Food and Drug Administration has approved midostaurin (Rydapt©) for the treatment of adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3, in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat© CDx FLT3 Mutation Assay, w


New Leadership | Alliance Respiratory Committee

April 17, 2017











The Alliance for Clinical Trials in Oncology is pleased to announce that Thomas Stinchcombe, MD, has been selected to serve as the Chair of the Alliance Respiratory Committee. Dr. Stinchcombe is a Professor of Medicine at Duke University, where he was recently recruited to help lead clinical research in thoracic oncology at the Duke Cancer Institute. Prior to this, Dr. Stinchcombe led the tho


Open Access Data-Sharing Model | NEJM Article

March 27, 2017

"It is important to honor and reward the altruism of patients who participate in clinical trials. One way to do so is to share the data gathered in clinical trials with other researchers in a responsible and meaningful way. The cancer research community, encouraged by recommendations from the Beau Biden Cancer Moonshot, is finally moving data sharing forward from its traditional, largely unfunded, place at the end of th


Alliance News Vol 7 No 1

March 9, 2017

 

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Alliance Trial Results Lead to FDA Approval of Maintenance Lenalidomide for Myeloma

February 24, 2017

The drug lenalidomide (Revlimid®) has been approved by the U.S. Food and Drug Administration (FDA) as maintenance therapy for patients with multiple myeloma following autologous stem cell transplant (ASCT). The current approval is based on two randomized, controlled trials evaluating the efficacy and safety of lenalidomide maintenance therapy for the treatment of multiple myeloma


Call for Nominations | Alliance Respiratory Committee

February 9, 2017

Everett Vokes, MD, of the University of Chicago, will be stepping aside after a spectacular tenure as Chair of the Alliance Respiratory Committee. The Alliance for Clinical Trials in Oncology is very grateful for his outstanding leadership, which has produced a multidisciplinary respiratory committee that is innovative, collegial and highly supportive of junior investigators. The Alliance is also very proud of the


New Leadership | Alliance Cancer in the Elderly Committee

February 8, 2017











The Alliance for Clinical Trials in Oncology Executive Committee has approved the nominations of two Alliance members to co-lead the Cancer Control Program’s Cancer in the Elderly Committee.

Arti Hurria, MD | Co-Chair – Alliance Cancer in the Elderly Committee
Dr. Hurria is a Professor in the Department of Medical Oncology and Therapeutics Research & Departme


Call for Nominations | Alliance Health Outcomes Committee

January 10, 2017

 

 

 

 



Ethan Basch, MD, MSc, and Jeffrey A. Sloan, PhD, will be stepping down as Co-Chairs of the Alliance Health Outcomes Committee effective August 1, 2017 after five years of distinguished leadership service with the Alliance and many years of leadership with its legacy groups. They have both made seminal contributions in methods for collecting and analyzing pa


Alliance News Vol 6 No 5

December 20, 2016

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Alliance Leaders Elected to ASCO Posts

December 16, 2016

Alliance Group Chair Monica M. Bertagnolli, MD, has been elected to serve as the President of the American Society of Clinical Oncology (ASCO) for the term beginning in June 2018. She will take office as President-Elect during the ASCO Annual Meeting in Chicago in June 2017. Dr. Bertagnolli is Chief of the Division of Surgical Oncology at Dana-Farber/Brigham and Women's Cancer Center, a Professor of Surgery at Harvard Medica


Alliance Researchers To Present Novel Data at 2016 ASH Meeting

November 30, 2016


The Alliance for Clinical Trials in Oncology will present an array of novel data from many of its hematology studies during the 58th American Society of Hematology (ASH) Annual Meeting and Exposition December 3-6 in San Diego, CA. Many of these data will help change the delivery of hematologic cancer care or help elucidate the underlying cause and effect relationships seen in this field.

Here is a


Call for Nominations | Alliance Cancer in the Elderly Committee

November 29, 2016

 

Effective August 1, 2017, Harvey Cohen, MD, (left) and Hyman Muss, MD, will step down as Co-Chairs of the Alliance Cancer in the Elderly Committee after five years of distinguished leadership service with the Alliance and 15-plus years with Cancer and Leukemia Group B (CALGB). The Alliance has been fortunate for their exceptional leadership and contributions in the area of cancer in the elderl


Alliance Board of Directors Elects New Group Statistician

November 10, 2016

The Alliance for Clinical Trials in Oncology is pleased to announce that Sumithra J. Mandrekar, PhD, has been elected by our Board of Directors to serve as the Group Statistician.

Dr. Mandrekar is a Professor of Biostatistics and Oncology at the Mayo Clinic.


2016 Alliance Fall Group Meeting Presentations Available Online

November 7, 2016

Meeting presentations from the 2016 Alliance Fall Group Meeting November 2-5 in Rosemont, IL are available online. Be sure to check throughout the week for additional materials that will be posted as they become available. Also, check out a few highlights from the meeting on Facebook and Twitter (search #AllianceFallGrpMtg2016).

 


2016 Alliance Fall Group Meeting Materials Availabe Now

November 1, 2016
 

The Alliance Meeting Book, committee agendas and meeting presentations for the 2016 Alliance Fall Group Meeting November 2-5 in Chicago are now available on the Alliance website for Alliance members.
 
All meeting materials (including the book, agendas and presentations) can be found on the member side in the Quick Links section under Meeting Presentations &am

Alliance Announces Interim Alliance Group Statistician

October 12, 2016

The Alliance for Clinical Trials in Oncology proudly announces that Sumithra Mandrekar, PhD, has agreed to serve as Interim Group Statistician while the search for a new leader of the Alliance Statistics and Data Management Program begins. Dr. Mandrekar is a Professor of Biostatistics and Professor of Oncology at the Mayo Clinic. She comes to the role with outstanding experience in National Clinical Trials Network


Tragic News - Alliance Group Statistician

September 23, 2016

Dear Alliance Members and Friends,

It is with profound sadness that I write to inform you of the loss of our dear friend and colleague, Dan J. Sargent, PhD.  Dan passed away yesterday as the result of a sudden, unexpected illness.

It is difficult to express the magnitude of this loss for all of us.  Dan's wonderful collaborative personality brought people together to achieve tremendous goals for the fi


Alliance Cancer Control Program Presents Funding Awards to Four Investigators

August 31, 2016

Four Alliance investigators have been selected to receive funding awards through the Alliance Cancer Control Program (CCP). The Alliance NCORP Research Base, which is supported by the NCI Division of Cancer Prevention (DCP), supports Alliance researchers and junior investigators and their work through annual funding awards: Alliance CCP Pilot Project Award and Alliance CCP Junior Faculty Awar


New Alliance Co-Chair | NCI CCDR Coordinating Committee

August 30, 2016

An Alliance researcher has been nominated and selected to serve as Co-Chair for the National Cancer Institute's Cancer Care Delivery Research (CCDR) Coordinating Committee. George J. Chang, MD, MS, FACS, FASCRS, will join two others (Ruth Carlos, MD, and Matthew Hudson, MD) in the co-chair positions. Dr. Chang is a Professor in the Department of Surgical Oncology-Division of Surgery; Chief in the Section of Co


Alliance News Vol 6 No 3

August 26, 2016

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Alliance at ASCO 2016

May 26, 2016 | PDF Version

The 52nd Annual Meeting of the American Society of Clinical Oncology (ASCO) will convene in Chicago June 3-7, bringing together more than 34,000 oncology professionals from around the world. This year's meeting theme, "Collective Wisdom: the Future of Patient-Centered Care and Research," focuses on the power of combining knowledge - across disciplines, disease sites, and treatment approaches - to evolve and shape the futur


Alliance News Vol 6 No 2

May 18, 2016

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Alliance News Vol 6 No 1

March 4, 2016

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Planned Outage | Alliance Online Apps + Member Site | Sat Dec 5, 8 am - Sun Dec 6, 12 pm

December 2, 2015

The Ingres database will be upgraded Saturday, December 5 starting at 8 am, which means OPEN registrations and RDTS will be off line during this time, along with JCCS Remote Data Capture, Alliance member web pages and legacy ACOSOG and NCCTG web pages. Alliance Operations and Statistical staff should log out of XWin/NX Clients applications at the end of the day on Friday, December


Alliance Member Website Planned Outage | Sunday, November 22

November 19, 2015

The Alliance member website is scheduled for a planned outage (as part of the Ingres Upgrade) 8 am to 12 pm Sunday, November 22. Servers that support the member website will be upgraded. The outage will affect all Alliance member site web pages.

 

Alliance Researchers Approved for $4.3M Multi-Year Research Funding Awards from PCORI

October 12, 2015

Two Alliance researchers recently were approved to receive multi-year awards from the Patient-Centered Outcomes Research Institute (PCORI) to fund comparative effectiveness research that will help patients and their providers make better informed decisions about their care, including cancer care. Ronald C. Chen, MD, MPH, of University of North Carolina at Chapel Hill, and Deborah Sch


Call for Posters | 2015 Alliance Fall Group Meeting

September 11, 2015

The Alliance for Clincial Trials in Oncology will host a Poster Session during the 2015 Alliance Fall Group Meeting in Chicago, IL. More than 1,100 investigators, nurses, CRPs, and administrative personnel from across the country are gathering to communicate their latest findings relating to the prevention and treatment of cancer. These presentations will be integral to the meeting.

If you are an Alliance membe


Planned Outage: Alliance Member Website Down Sept 12 8:30p-10p

September 10, 2015

Due to a planned outage, there will be no access to the Alliance member website Saturday, September 12 from 8:30 pm to 10 pm. The production server that the Ingres database runs on will be offline due to an operating system patch. The outage will affect all Cancer Center applications; protocol catalog; all member web pages for the Alliance, CPN, MCCRC, Phase 2, Spore and NCCTG; and the Cancer Center Syst


AFT Launches PALLAS Trial

August 26, 2015

Alliance Foundation Trials and Austrian Breast & Colorectal Cancer Study Group Open Largest Global Phase III Trial of Targeted Therapy, IBRANCE® (palbociclib), for Patients with Hormone Receptor-Positive Early Breast Cancer

Partnership with Pfizer, BIG, GBG, NSABP and PrECOG to facilitate further investigation of IBRANCE

NEW YORK, NY, August 26, 2015 -- The Alliance Foundation Trials, LLC (AFT), the Austrian Breast & Co


Alliance News Vol 5 No 3

July 2, 2015

 

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Alliance at ASCO 2015

June 1, 2015

Investigators from the Alliance for Clinical Trials in Oncology will present and/or publish more than 30 abstracts as part of the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago May 30-June 2. Here's a quick list of Alliance and Alliance associated abstracts.


Alliance News Vol 5 No 2

May 8, 2015

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In Memoriam: Andrew Parsa, MD, PhD

April 15, 2015

From Alliance Group Chair | Monica M. Bertagnolli, MD

It is with great sadness that I inform you of the death of our colleague, Dr. Andrew Parsa, who passed away of a currently undetermined medical condition at the age of 48.

Andy was a key member of the Alliance NeuroOncology Committee. At the time of his death, Andy was the Chair of Neurosurgery at Northwestern University, and also held the Michael J Marchese Chair in Neuros


Alliance Researchers to Identify Biomarkers to Predict Brain Metastatic Behavior in Patients with NSCLC

March 24, 2015

Alliance researchers at Washington University School of Medicine and the Siteman Cancer Center have been awarded $1.47 million to study whether a tumor’s DNA sequence can predict brain metastasis in patients with non-small cell lung cancer (NSCLC). Mark Watson, MD, PhD, Associate Professor of Pathology and Immunology, and Ramaswamy Govindan, MD, Professor of Med


In Memoriam: Meir Wetzler, MD, and Mark Green, MD

February 27, 2015

From Alliance Group Chair | Monica M. Bertagnolli, MD

It is with great sadness that I write to announce the untimely loss of two of our exceptional friends and colleagues - Mark Green, MD, and Meir Wetzler, MD.

Mark passed away February 23. He had been battling plasma cell leukemia for some time. Mark joined the Cancer and Leukemia Group B (CALGB) in 1979, and served the Group in many leadership roles. He was


Alliance News Vol 5 No 1

February 13, 2015

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Alliance Presents Novel Data at ASH Annual Meeting

February 3, 2015

The Alliance for Clinical Trials in Oncology presented an impressive array of novel data from many of its hematology studies during the 56th American Society of Hematology (ASH) Annual Meeting and Exposition held in San Francisco, CA. Many of these data will help change the delivery of hematologic cancer care or help elucidate the underlying cause and effect relationships seen in this field. Here is a list of the Alli


Alliance News Vol 4 No 6

December 1, 2014

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Alliance News Vol 4 No 5

October 1, 2014

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Alliance Board Appoints Kelly Hunt to Lead ACS Clinical Research Program

September 15, 2014

The Alliance Board of Directors recently announced the appointment of Kelly K. Hunt, MD, FACS, to the position of Director of the American College of Surgeons Clinical Research Program. This Alliance Program is the home of Cancer Care Delivery Research for our group, and also involves an important collaboration with the Commission on Cancer and the American College of Surgeons.

Dr. Hunt is


Alliance, NCI Networks Launch Integrated Lung Cancer Trials Called ALCHEMIST

August 18, 2014

The Alliance for Clinical Trials in Oncology, in conjunction with the National Cancer Institute (NCI) and ECOG-ACRIN Cancer Research Group, today launched the Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials, or ALCHEMIST – three trials to identify patients with early-stage lung cancer who have tumors that contain uncommon genetic changes and evaluate whether d


Alliance News Vol 4 No 4

July 3, 2014

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Alliance News Vol 4 No 3

May 6, 2014

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Alliance News Vol 4, No 2

February 20, 2014

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NCI NCTN Transition Update

February 17, 2014

As of March 1, 2014, the cooperative group system will transition to the NCTN.
Click here to learn about what this transition entails.


Alliance News Vol 4, No 1

January 23, 2014

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Alliance News Vol 3, No 9

December 12, 2013

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Alliance Offices Holiday Closures

  • December 24:
    • Chicago Operations Office (closing at 3:00 p.m. CST)

    • Office of the Group Chair in Boston

    • Statistical & Data Management Center at Duke (closing at 3:00 p.m. EST)

    • Statistical & Data Center at Mayo (closing at 3:00 p.m. CST)

    • Registration Office at Mayo (closing at 3:00 p.m. CST)

  • December 25:

Center for Biomedical Informatics Scheduled Application Downtime

November 22, 2013
 

The Center for Biomedical Informatics (CBMI) at Washington University School of Medicine in St. Louis will upgrade its Information Technology (IT) infrastructure by moving its hardware to a new facility. In order to facilitate this move and at the same time to minimize the impact to our user community, we will execute this move primarily over the week of the Thanksgiving holiday in th


Alliance News Vol 3, No 8

September 30, 2013

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Alliance News - Vol 3, No 7

August 8, 2013

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Alliance News - Vol 3, No 6

June 13, 2013

 

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Alliance News - Vol 3, No 5

May 7, 2013

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Alliance News - Vol 3, No 4

April 4, 2013

 

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Alliance News - Vol 3, No 3

March 6, 2013

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Alliance Group Biorepository Director Selection

February 27, 2013



In Fall of 2013, Alliance will be submitting a funding application to the NCI that will replace the current U24 biorepository awards held by our three component groups, CALGB, ACOSOG, and NCCTG.  I am writing to issue a call for nominations for this Principal Investigator position.  Individuals who are eligible must have a high level of expertise in biorepository management and cancer biomarker development


2013 Richard L . Schilsky CALGB Achievement Award

February 27, 2013



The Richard L. Schilsky Cancer and Leukemia Group B Achievement Award was established in 2010 to recognize the 15-year tenure of Dr. Schilsky as Group Chair of CALGB.  The award acknowledges the significant contributions of an individual to cooperative group research.  As an organization, it is vital for the Alliance to identify and honor the talented people respon


Alliance News - Vol 3, No 2

February 1, 2013

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Alliance Holiday Closures

December 27, 2012
Alliance Offices will be closed next week as follows:
Closing early (2:00 PM ET) on December 31:

  • The Alliance Statistics and Data Center at Duke University

Closed December 31:

  • Alliance Chicago Operations Office
  • Office of the Group Chair in Boston
  • Alliance Statistics and Data Center at Mayo Clinic and Alliance Mayo Rochester Operations Office
    • Registration (NCCTG) will take registrations unt

Alliance News - Winter: Vol 3, No 1

December 20, 2012

 

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CALGB Information Systems and Patient Registration System Outage

December 5, 2012



The Alliance will be consolidating information systems from multiple sites to a single data center this weekend, December 7, 2012.  This consolidation will require a weekend outage primarily impacting legacy CALGB systems beginning Friday, December 7 at 6:00 PM EST until the anticipated return of services by 9:00 AM EST on Monday, December 10.

All applications as well as the CALGB website (c


Data Center Consolidation December 7-10, 2012

November 26, 2012



The Alliance will be consolidating information systems from multiple sites to a single data center the weekend of December 7, 2012.  This consolidation will require a weekend outage primarily impacting legacy CALGB systems beginning Friday, December 7 at 6:00 PM EST and anticipate the return of services by 9:00 AM EST on Monday, December 10. 

Additional email communications will be sent prior to the outa


Alliance Chicago Office and SDC Office at Duke University Holiday Closure

November 19, 2012

 

Please note that the Alliance Chicago Office will be closed on Thursday, November 22, and Friday, November 23, 2012 for the Thanksgiving holiday. The Alliance Chicago Office also will be closed on Monday, December 24, and Tuesday, December 25, 2012, for the Christmas holiday, and on Monday, December 31, 2012, and Tuesday, January 1, 2013 for New Year's.

The Alliance SDC Offic


Alliance News - Fall: No 2, Vol 9 Posted

November 12, 2012

 

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Alliance News - Fall: No 2, Vol 8 Posted

September 10, 2012

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Alliance News - Summer: Vol 2, No 7 Posted

August 9, 2012

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Alliance Group Meeting Poster Session

May 17, 2012

Greetings Alliance Members,

We would like to feature your recent scientific posters at the Alliance 2012 Group Meeting in Chicago on June 28 - 30.

If you recently presented a poster at a scientific meeting (2011-2012) related to cooperative group research, please bring it to the Alliance meeting. Posters will be displayed during the reception on Friday, June 29. Please e-mail kefaherty@partners.org to notify us if you will be bringing a poster by 5:


Alliance News - Spring: Vol 2, No 6 Posted

June 11, 2012

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Alliance News - Spring: Vol 2, No 5 Posted

April 6, 2012

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Alliance News - Winter: Vol 2, No 4 Posted

April 5, 2012

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Alliance News - Winter: Vol 2, No 3 Posted

March 15, 2012

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Alliance Membership Application Updated

February 21, 2012

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Alliance News - Winter: Vol 2, No 2 Posted

February 16, 2012

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Deadline Extended for Alliance for Clinical Trials in Oncology Foundation Awards

January 30, 2012

The Alliance for Clinical Trials in Oncology Foundation invites Alliance institution researchers to submit applications for 2012 Clinical Scholar Award and 2012 Investigator Award by February 20, 2012.

Applications should propose studies that assess interventions in cancer patients and/or examine biological specimens obtained from cancer patients.

General Guidelines for Applicants

  • Exclusively for oncolog