The Alliance for Clinical Trials in Oncology is committed to sharing the findings of our research in a clear, accessible, and meaningful way. The clinical trial results summaries below highlight findings from published Alliance clinical trials and translate key results into resources that can help others better understand what was learned.
Browse by cancer type
- ACOSOG Z1071: Trial that evaluated the role of sentinel lymph node dissection (SLND) surgery and axillary lymph node dissection (ALND) surgery after chemotherapy in patients with breast cancer that has spread to the lymph nodes in the breast area
- ACOSOG Z1072: Trial that looked at developing a new non-surgical treatment technique for adults with breast cancer
- CALGB 9343: Trial that compared two kinds of treatments for women who were at least 70 years old and had early (stage I) breast cancer that depended on the hormone called estrogen (called ER-positive or ER+)
- CALGB 9840: Trial that compared timing and different ways to give treatment to patients whose breast cancer had spread to other parts of their body (called metastatic)
- CALGB 40101: Trial that compared two different treatments for breast cancer patients who had no lymph nodes with cancer, or who had 1-3 lymph nodes with cancer. It also tested if 4 or 6 treatments worked better
- CALGB 40302: Trial that compared one drug to a combined treatment for women with advanced breast cancer that depends on a hormone called estrogen (ER-positive or ER+)
- CALGB 40502: Trial that compared different drug treatments (chemotherapy) for adults with breast cancer that has returned or spread throughout the body (metastatic breast cancer)
- CALGB 40503: Trial that compared two different drug treatments in women beyond child-bearing age, with breast cancer that was hormone receptor-positive and had spread locally or to other areas of the body where surgery was no longer a treatment choice (advanced breast cancer)
- CALGB 40601: Trial that compared different drug treatments (chemotherapy) in patients with HER2 positive (or HER2+) breast cancer that can be removed by surgery
- CALGB 40603: Trial that compared different drug treatments (chemotherapy) given before surgery for patients with triple-negative breast cancer, which is breast cancer without estrogen receptor (ER), progesterone receptor (PR) or HER2
- CALGB 49907: Trial that compared different chemotherapy (drug) treatments ways to treat older women with early breast cancer who are at least 65 years old; also other studies were included that examined quality of life for women in the trial and whether or not they took their medications as prescribed
- CALGB 369901: Trial that looked at whether survivorship care plans improved how women age 65 and over felt one year after finishing treatment for breast cancer
- NCCTG N063D: Trial that compared different drug treatments given after surgery for patients with HER2 positive breast cancer
- NCCTG N9831: Trial that compared different ways to give chemotherapy (drug) treatments to people with breast cancer that is called HER2/neu positive (HER2+)
- NCCTG N10C2: Trial compared magnesium oxide to placebo to see if it lowered hot flashes in breast cancer survivors who did not have monthly menstrual periods (menopausal)
- NCCTG N0572: Trial that examines the best dose of sorafenib and temsirolimus in patients with glioblastoma that has returned
- NCCTG N0574: Trial that compared different radiation therapy treatments for patients with cancer that has spread to the brain
- NCCTG N0776: Trial that combined two drug treatments to treat people with brain tumors that have come back (a recurrence)
- NCCTG N0779: Trial that combined two drugs together to treat people with glioblastoma, a kind of brain tumor
- NCCTG N09C6: Trial that compared medicine mouth rinses for people who get radiotherapy to treat head and neck cancers and who developed mouth sores from their treatment
- NCCTG N107C: Trial that compared different types of radiation treatment given to patients after removing a metastatic brain tumor
- NCCTG N0871: Trial that compared different drug treatments in patients with previously untreated cancer of unknown primary. Unknown primary is a term for a diagnosis given when metastatic cancer (cancer that has spread) is found in the body, but doctors cannot find where the original or primary cancer started.
- Alliance A021501: Trial that looked at both chemotherapy alone and chemotherapy followed by radiation therapy before pancreatic cancer surgery
- Alliance A021502: Trial that compared standard chemotherapy treatment alone or in combination with atezolizumab after surgery in people with a type of colon cancer called stage III colon cancer with deficient DNA mismatch repair
- ACOSOG Z6051: Trial that compared two types of surgery currently used in rectal cancer
- Alliance A021101: Pilot study that compared different chemotherapy (drug) treatments before surgery for adults with pancreatic cancer
- CALGB 80303: Pancreatic cancer clinical trial that compared two treatments for people whose cancer could not be removed by surgery
- CALGB 80403: Trial that compared different drug (chemotherapy) treatments for patients with esophageal cancer or gastroesophageal junction cancer that has spread to other places in the body
- CALGB 80405: Trial that compared different chemotherapy (drug) treatments for adults with colon or rectal cancer that has returned or spread throughout the body
- CALGB 80802: Trial that compared the effectiveness of sorafenib plus doxorubicin to sorafenib alone for the treatment of advanced hepatocellular carcinoma (HCC), commonly known as liver cancer
- CALGB 89803: Trial that determined whether patients whose stage III colon cancer came back (called a recurrence) lived longer if they exercised after they received one of two different chemotherapy treatments
- NCCTG N08CB: Trial that compared one dose to two doses of calcium and magnesium to a placebo (an inactive agent) for the prevention of a common side effect, called neuropathy (numbness and tingling), caused by the drug oxaliplatin, which is often used to treat patients with colon cancer
- Alliance A031203: Trial that compared different drug treatments in patients with newly found kidney cancer that had spread from where it started to nearby tissue or to other places in the body
- CALGB 70903: Trial that reviewed a pain survey to see how it measured pain in men with a kind of prostate cancer that spread in their body (metastatic) and was called castrate-resistant
- CALGB 90401: Trial that compared cancer drug treatments after hormone treatment stopped working for men with prostate cancer that spread to other parts of their body (called metastatic)
No summaries available at this time
- Alliance A041202: Trial that looked at three different treatments in patients who had chronic lymphocytic leukemia (CLL) who were 65 or older
- CALGB 9011: Trial that compared different chemotherapy (drug) treatments to see if a drug called fludarabine raised the number of patients with chronic lymphocytic leukemia (CLL) who get a second kind of cancer
- CALGB 9720: Trial in acute myeloid leukemia (AML) that compared different ways to give treatment to patients who were 60 years and older
- CALGB 10001: Trial that compared two kinds of stem cell transplants and a newer drug for people with Philadelphia-positive acute lymphoblastic leukemia (ALL) along with cancer drug treatment (chemotherapy)
- CALGB 10503: Trial that measured how age affects the time it takes for the drug busulfan to leave patients’ bodies when it is given as part of a stem cell transplant
- CALGB 10603: Trial that compared different chemotherapy treatment drugs in patients with leukemia cells with the abnormal FLT3 gene
- CALGB 50202: Trial that looked at a new drug treatment (chemotherapy) for patients with newly diagnosed lymphoma in the central nervous system (CNS), which is commonly in the brain and spinal cord
- CALGB 50401: Trial that compared different drug (chemotherapy) treatments in patients with follicular non-Hodgkin lymphoma
- CALGB 50904: Trial that looked at whether adding bortezomib to ofatumumab + bendamustine in patients with untreated follicular lymphoma lived longer and/or lived more time before the disease worsened
- CALGB 59804: A Hodgkin lymphoma clinical trial that examined a chemotherapy (drug) treatment to see if this treatment is effective and has tolerable side effects in patients whose disease had returned (called a recurrence) or had not responded to prior treatments (called resistant)
- NCCTG N0775: Trial that compared two different drug treatments for patients who have melanoma that has spread to other parts of the body (called metastatic) and cannot be removed with surgery
- CALGB 100104: Trial that compared a new drug treatment to no additional treatment for patients with multiple myeloma (a type of blood cancer) after they had a stem cell transplant
- CALGB 30402: Trial that compared two new drugs given to patients whose cancer spread beyond the lungs (called metastatic)
- CALGB 30607: Trial that determined how well a drug worked after treatment of chemotherapy in patients with stage IIIB-IV non-small cell lung cancer
- CALGB 30801: Trial that compared two treatments for patients with advanced non-small cell lung cancer
- CALGB 31001: Trial that compared different surgeries to remove lung cancer tumors to see which had better results for patients
- CALGB 31102: Trial that determined if it was safe to give radiation therapy over shorter lengths of time for patients with locally advanced (stage 3) lung cancer
- CALGB 70601: Trial that compared whether or not a patient’s education made a difference in how long they lived
- CALGB 70602: Trial that compared the results of chemotherapy (drug) treatment based on where it was given to patients
- NCCTG N0821: Trial that measured a cancer treatment for patients with advanced non-small cell lung cancer who were at least 70 years old
- CALGB 10001: Trial that compared two kinds of stem cell transplants and a newer drug for people with Philadelphia-positive acute lymphoblastic leukemia (ALL) along with cancer drug treatment (chemotherapy)
- CALGB 10503: Trial that measured how age affects the time it takes for the drug busulfan to leave patients’ bodies when it is given as part of a stem cell transplant
Rare tumors
- Alliance A091102: Trial that looked at how well a drug worked in treating patients with sarcoma that had spread to other places in the body and usually could not be cured or controlled with treatment or had spread to other places in the body
- Alliance A091103: Trial that looked at a drug treatment for patients with a type of cancer called angiosarcoma that has spread through the body and could not be removed with surgery
- Alliance A091401: Trial that looked at giving nivolumab alone or nivolumab and ipilimumab to treat patients with metastatic sarcoma
- Alliance A091105: Trial that looked at using the drug sorafenib to treat desmoid tumors (aggressively growing fibromatosis)
Other conditions
- CALGB 60301: Trial that tried to find out a safe dose of sorafenib (a cancer drug which is also called Nexavar) for patients with cancer whose liver or kidneys were not working properly
- CALGB 70903: Trial that reviewed a pain survey to see how it measured pain in men with a kind of prostate cancer that spread in their body (metastatic) and was called castrate-resistant
- CALGB 170601: A phase III double-blind trial of oral duloxetine for treatment of pain associated with chemotherapy-induced peripheral neuropathy (CIPN)
- NCCTG N02C4: Trial that looked at whether taking creatine supplement would increase weight and appetite in patients with weight loss caused by cancer
- NCCTG N08CB: Trial that compared one dose to two doses of calcium and magnesium to a placebo (an inactive agent) for the prevention of a common side effect, called neuropathy (numbness and tingling), caused by the drug oxaliplatin, which is often used to treat patients with colon cancer
- NCCTG N08C3: Trial compared two treatments to lower the amount of nausea and vomiting (getting sick to the stomach) due to cancer treatment (chemotherapy)
- NCCTG N0993: Trial that compared three other studies that all used the same tools to measure skin rash symptoms in patients who received treatments like radiation or targeted therapies to see how the tools compared
- NCCTG N10C1: Trial that looked at three different treatments to improve vaginal symptoms of dryness or pain with intercourse in postmenopausal women who had a history of either breast or gynecologic cancer
- NCCTG N10C2: Trial that compared magnesium oxide to placebo to see if it lowered hot flashes in breast cancer survivors who did not have monthly menstrual periods (menopausal)
- CALGB 70601: Lung cancer trial that compared whether or not a patient’s education made a difference in how long they lived
- CALGB 70602: Lung cancer trial that compared the results of chemotherapy (drug) treatment based on where it was given to patients
- CALGB 89803: Trial that determined whether patients whose stage III colon cancer came back (called a recurrence) lived longer if they exercised after they received one of two different chemotherapy treatments
- CALGB 369901: Trial that looked at whether survivorship care plans improved how women age 65 and over felt one year after finishing treatment for breast cancer.
Looking for specific trial information?
For additional information on completed trials, visit ClinicalTrials.gov to search for individual clinical trials and access available trial information. ClinicalTrials,gov records may also include links to publications reporting trial results, including those available through PubMed and PubMed Central for trial data. You can also research using the Alliance publication search tool.
To explore Alliance trials that are currently enrolling participants, visit our Clinical Trials page.
Thank you to our trial participants
Every clinical trial depends on the people who choose to participate. We are deeply grateful to the patients and families who have taken part in Alliance clinical trials and to the investigators, research teams, and communities who have made these clinical trials possible.