(or Press Releases): Covering trial activations and trial results.
Recently activated phase II clinical trial will evaluate post‑operative radiation in non-small cell lung cancer The Alliance for Clinical Trials in Oncology has launched a new clinical research study to explore whether a more targeted form of radiation therapy lowers the chance of lung cancer returning after surgery. The study (Alliance A082402) is for people…
NCI-sponsored study evaluates whether aggressive local therapy improves survival for limited metastatic colorectal cancer The ERASur (Evaluation of Resection or Ablation for Limited Metastatic Colorectal Cancer) clinical trial has reached a major enrollment milestone, with more than one-third of its targeted patients now accrued, signaling strong momentum for this national study. ERASur (Alliance A022101) is investigating…
Immunotherapy combined with chemotherapy before surgery improves outcomes for patients with stage III non-small cell lung cancers New findings of an Alliance Foundation Trials study show combining immunotherapy and chemotherapy before surgery improves outcomes for some patients with locally advanced non-small cell lung cancer, according to the results of AFT-46/CHIO3 published in Lung Cancer. “These…
The Alliance for Clinical Trials in Oncology has recently launched several new clinical trials exploring targeted radiation therapy, improved treatment strategies and other innovative approaches to cancer care. From testing new drug combinations for rare and aggressive cancers to evaluating digital health tools that improve access to genetic services, these trials aim to improve outcomes, reduce…
Alliance trial will test whether laser therapy reduces vaginal dryness caused by cancer medications The Alliance for Clinical Trials in Oncology is now enrolling patients into a clinical trial aimed at helping women recover from the vaginal side effects of breast cancer treatment. Supported in part by a grant from the National Cancer Institute, the…
Randomized Alliance trial shows duloxetine does not prevent painful neuropathy caused by chemotherapy A randomized trial conducted by the Alliance for Clinical Trials in Oncology with support from the National Cancer Institute has found that duloxetine, a medication commonly used to treat chronic pain and psychiatric conditions, does not prevent nerve damage caused by chemotherapy…
Published results show adjuvant atezolizumab plus mFOLFOX6 significantly reduces recurrence risk and delivers the first proven immunotherapy benefit in early stage dMMR disease. A new study from researchers at the Alliance for Clinical Trials in Oncology (Alliance) shows that patients with stage III colon cancer with deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) had significantly…
A new clinical trial led by the Alliance for Clinical Trials in Oncology will investigate if a combination of drug therapies after radiation therapy improves outcomes for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma, a type of brain cancer. Supported in part by a grant from the National Cancer Institute, the study (Alliance A072301) will…
Twice-daily radiation therapy associated with improved survival in limited-stage, small-cell lung cancer Immunotherapy given during and after chemoradiation did not improve survival for study participants with limited-stage, small-cell lung cancer (SCLC) according to the results of an international clinical trial, NRG-LU005, led by NRG Oncology in collaboration with the Alliance for Clinical Trials in Oncology. The…
Study will use two oral targeted cancer therapies for adults over 65 The Alliance for Clinical Trials in Oncology has launched a new clinical trial for adults who need first-line therapy for chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study (Alliance A042302) will explore whether combining two targeted medicines, zanubrutinib and sonrotoclax,…